Adonis Blackwell is set to take his drug empire and expand it from city to city by flooding the streets with the deadly painkiller fentanyl. He sends his cousin Silk Blackwell to Pittsburgh to take over the market.
In Washington D.C. the opioid epidemic is claiming lives. Adonis Blackwell continues to climb the food chain by any means necessary and the painkiller fentanyl expedites his process. There is also a war going on between two hip hop crews from rival neighborhoods.